Book Abstract
Innovations in Aortic Valve Disease traces the full arc from cellular mechanisms to cutting-edge treatment modalities. Integrating insights from molecular biology, engineered devices, robotics, AI, and pharmacotherapy, this book charts a visionary future: one in which AVD management becomes more personalized, less invasive, and more preemptive?transforming both survival and quality of life.
Aortic valve disease (AVD), particularly calcific aortic stenosis (AS), has transitioned from a surgically managed condition to one deeply informed by mechanistic insights, imaging breakthroughs, and minimally invasive therapies. Innovations in Aortic Valve Disease offers a comprehensive exploration?from molecular drivers to advanced interventions and emerging therapies?illuminating the evolving landscape of valve care.
Calcific AVD is initiated by endothelial injury and lipid oxidation, activating inflammatory and osteogenic signaling in valve interstitial cells. Novel molecular insights have identified targets such as antiproliferative agents (e.g., paclitaxel-eluting valvuloplasty balloons) and nitric oxide modulators (e.g., ataciguat), which in preliminary trials have reduced calcification progression by ~70% over six months in moderate AS.
