Book Abstract
Inflammatory Bowel Disease Revisited merges cutting-edge mechanistic insights?spanning immunology, microbiomics, and genetics?with advanced diagnostics and therapeutic innovations. From ultrasound and AI diagnostics to biologics, neuromodulation, microbe-targeted therapies, and nanotechnology-enhanced drug delivery, this volume equips clinicians and researchers to deliver precision-guided, integrative IBD care.
Inflammatory Bowel Disease (IBD)?encompassing Crohn?s disease (CD) and ulcerative colitis (UC)?is a complex, chronic condition driven by genetic predisposition, immune dysregulation, microbiome imbalance, and environmental triggers. This book provides a forward-looking synthesis that bridges pathophysiological mechanisms with evolving diagnostics and personalized clinical care.
Numerous susceptibility loci identified through GWAS reveal immune-regulatory genes (e.g., NOD2, ATG16L1). Additionally, a novel enhancer in a ?gene desert? activating ETS2 has been linked to macrophage-mediated inflammation?opening avenues for MEK-inhibitor repurposing
