Book Abstract
Heart Transplantation: Evolving Therapies and Insights presents a holistic, future-facing blueprint for HTx. By weaving together multi-omic surveillance, regenerative biology, organ rescue technologies, immunologic innovation, and AI-enhanced practice, this volume outlines a new paradigm in which heart transplantation becomes more precise, accessible, and sustainable?ushering in a next generation of care for patients with end-stage heart disease.
Heart transplantation (HTx) remains a life-saving option for end-stage heart failure, yet is challenged by donor shortages, immune rejection, long-term graft injury, and the need for advanced patient monitoring. Heart Transplantation: Evolving Therapies and Insights explores transformative innovations?spanning regenerative medicine, precision immunology, organ rehabilitation, and artificial intelligence (AI)?that collectively aim to improve both graft and patient outcomes.
Multi-omics approaches?including donor-derived cell-free DNA, transcriptomics with microRNA panels, proteomics, metabolomics, and single-cell sequencing?are emerging as non-invasive, individualized biomarkers for early detection of rejection, primary graft dysfunction, and cardiac allograft vasculopathy, offering personalized risk stratification and mechanistic insight.
Genetic engineering and immunologically tailored xenotransplantation?such as porcine heart constructs?alongside stem-cell based cardiac regeneration (e.g., cardiac patches, engineered heart tissue), offer pathways to overcome organ scarcity and promote myocardial repair .
