Book Abstract
Extracellular Vesicles: Disease and Therapy in Focus explores the multifaceted roles of extracellular vesicles (EVs) in disease mechanisms and their emerging utility as diagnostic markers and therapeutic agents. EVs?nano- to micron-sized lipid-bound particles released by virtually all cell types?serve as natural carriers of proteins, lipids, RNAs (including miRNA, mRNA, lncRNA, circRNA), and metabolites.
This volume offers a cohesive and state-of-the-art perspective for cell biologists, clinicians, biomedical engineers, and translational researchers, synthesizing foundational science with applications across diagnostics, drug delivery, and regenerative medicine.
The book systematically reviews how EVs contribute to pathogenesis across major organs and diseases. The role of EVs in cardiovascular, renal, metabolic, and fibrotic diseases, illustrating how they promote inflammation, fibrosis, and cell?cell communication. EV signaling in diabetic complications?including retinopathy, cardiomyopathy, renal fibrosis, and wound healing?emphasizing stem cell?derived EVs? reparative effects in animal models. EVs as liquid-biopsy biomarkers, leveraging miRNA and protein cargo to enhance early detection, classification, and monitoring of cancer, neurodegeneration, and cardiopulmonary disorders.
