Book Abstract
Translating Science to Practice: Clinical Implementation of Bone Regeneration offers a comprehensive exploration of the journey from laboratory research to clinical application in bone tissue engineering.
The book delves into the evolution of biomaterials used in bone regeneration, including metals, bioceramics, and polymers. It examines their mechanical properties, biocompatibility, and osteoinductive potential, highlighting advancements such as 3D-printed scaffolds and nanocomposites. The integration of growth factors and stem cells into these materials is also discussed, emphasizing their role in enhancing osteogenesis and vascularization.
A critical analysis of preclinical models is provided, focusing on their relevance and limitations in mimicking human bone defects. The book addresses the "bench-to-bedside" gap, discussing challenges such as regulatory hurdles, scalability of manufacturing processes, and the need for standardized testing protocols. Case studies illustrate successful transitions from animal models to human trials, offering insights into effective strategies for clinical translation.
